Proteins: Globular,
Membrane, Fibrous
1. List the three
main classes of proteins and two distinguishing features of each.
2. Identify the most
significant force in determining the 30 structure of
globular proteins and list one secondary
way in which these proteins maintain their most active
conformation.
3. Describe the main
features of an enzyme and distinguish
between coenzymes and prosthetic
groups.
4. Describe a common
structural modification of circulating
globular proteins and indicate which specific residues are modified.
5. Compare glycosylation of circulating proteins
that occurs in a specific, enzyme-directed fashion with the glycosylation
that can occur in a spontaneous and uncontrolled (“non-enzymatic) fashion. How does “non-enzymatic” glycosylation provide
useful clinical information
concerning diabetic patients?
6. Identify which
domain of a membrane protein is usually glycosylated and how membrane glycoproteins
may contain a vast amount of biological “information”.
7. List three functional
categories of membrane proteins.
Proteins-Structural
1. Describe the secondary and tertiary structure
of mature collagen and explain
the importance of the many glycine residues.
2. List five different
modifications of amino acid residues in collagen. Identify the cofactors
required for these modification reactions.
3. Delineate the
steps in collagen maturation.
4. Identify the feature
unique to elastin plus one feature
it shares with collagen.
5. Describe an important
stabilizing modification of a-keratin and a simple
intervention to disrupt and then reform this type of modification.
©
Sturm 2016