Work Sheet 8
Gas Transport
1. Describe how the cooperative binding of oxygen
by hemoglobin makes it a better oxygen transporter.
2. Define the “R” (relaxed) and “T” (tense) states of hemoglobin.
3. Describe the relationship of the Bohr effect to oxygen binding by hemoglobin
and explain the physiological significance of this effect.
4. Discuss the effect of carbon dioxide (CO2) on hemoglobin
affinity for oxygen and the physiological relevance of this effect.
5. Explain the effect
of 2,3-bisphosphoglycerate (BPG) on hemoglobin affinity for oxygen
and how it facilitates oxygen release to tissues.
6. Explain why the low affinity of fetal hemoglobin for BPG is beneficial to the fetus.
Introduction
to Antibodies and Antigens
1. Diagram the basic
structure common to immunoglobulins.
2. Define the following terms related to immunoglobulin
structure: heavy chain, light
chain, constant region, variable region,
hinge region, Fab fragment, Fc fragment and complementarity-determining
regions (CDRs).
3. Describe the different forces involved in the binding of an antibody to its antigen and define the term hapten.
© Sturm 2016