Work Sheet 10

 

Enzymes: Isozymes and Regulation

 

1.      Define isozyme and nonfunctional plasma enzyme and discuss the importance of nonfunctional plasma enzymes as a diagnostic tool.

 

 

 

 

 

2.      Identify the brain, muscle, heart and liver isozyme patterns for creatine phosphokinase and lactate dehydrogenase.

 

 

 

 

3.      Describe how creatine phosphokinase and lactate dehydrogenase can be used in the diagnosis of myocardial infarction.

 

 

4.      Explain why a combined analysis of plasma glutamyl transpeptidase and alanine aminotransferase is desirable for diagnosing hepatitis in a patient.

 

 

 

5.      Define the following types of regulation of enzyme activity: substrate availability, allostery, post-translational modification, interactions with control proteins and zymogens.

 

 

6.      List 6 ways that proteins can undergo post-translational modification.

 

 

 

 

 

 

 

 

7.      Identify the 3 amino acids which can undergo phosphorylation.

 

© Sturm 2016

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