Work Sheet 17

DNA Mutation and Repair

1. Define the following mutations: point, silent, missense, nonsense and frameshift.

 

 

2. Define the terms transition and transversion.

 

 

3. Describe what is meant by a conservative and nonconservative mutation.

 

 

4. List four major ways that DNA can be damaged or mutated.

 

 

5. Outline the major steps of mismatch , nucleotide excision and recombination repair.

 

 

6. Outline the pathway by which p53 is believed to regulate DNA repair.

 

 

7. List four diseases that are attributed to defects in DNA repair.

 

© Sturm 2016

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