Biochemistry I, CHE 450

MW 10:00AM-11:40AM

Monday, On-Campus, II 3350

Wednesday, On-Line, Bb Collaborate Ultra

 

We will be 100% "virtual", on-line using Bb Collaborate Ultra, until Monday March 7th, 2022

Instructors: Dr. Noel Sturm (on-line) and Neema Masoudipour (on-campus)



E-Mail: nsturm@csudh.edu and nmasoudipour1@csudh.edu


Course Organization and Policies:

1. Prerequisites: (a) General Chemistry (1 year) and (b) Organic Chemistry w/ Laboratory (1 year or a 1 semester survey course w/ lab) and (c) Quantitative Analysis (may NOT be taken concurrently w/ Biochemistry 450).


2. REQUIRED Text: Lehninger: Principles of Biochemistry, 8th Edition; Authors: Nelson and Cox

We will be Using the myCSUDH-ImmediateAccess- program.

How Does It Work?

The required course ebook will be available in a digital format .

You will receive an email from Brytewave. It will say "The following materials have been added to your library at brytewave.redshelf.com: Lehninger: Principles of Biochemistry, 8th Edition".

You will receive Free Access on the first day of classes.

Discounted pricing, $89.99, has been negotiated with publishers.

Students will have until Friday, February 18th, 2022 to opt out of the program..

After the opt-out deadline, any students who has not opted out will be charged on their CSUDH student account by the university, allowing more time to pay for the required material.

3. The reading list consists of links (see below) for Lehninger that highlight the sections and sub-sections of each chapter that are important for understanding the chemistry of biological systems and are relevant to the questions you will be asked in the homework and on the exams.

 

4. Power Point Slides and Simplified Lecture Notes: The power point slides (.pptx) and simplified lecture notes (.html) are on-line, arranged via lecture topic, at: http://www2.csudh.edu/nsturm/. Examination questions will be derived directly from power point slides, reading and homework. The simplified lecture notes (.html) are provided as additional, alternative presentations of the material.

 

5. Hybrid Course: This is a hybrid course, we will meet on-campus every Monday (II 3350), beginning March 7th, and on-line every Wednesday, using Blackboard Collaborate Ultra, from 10:00AM-11:40AM. We will discuss lecture material, do quick thinks and answer questions. It is very important that you attend all of the on-campus and on-line sessions in order to succeed in this course. You must have a working computer, reliable internet connectivity and browser is an important requirement, please use Firefox 90.0.x or higher.

 

Instructions for Blackboard Collaborate Ultra:

https://help.blackboard.com/Collaborate/Ultra/Moderator/Get_Started/About_Collaborate

 

In Blackboard:

<Blackboard Collaborate Ultra

<Click-on the "Session"

<Click-on "Join Room"

 

6.Examinations: There will be four examinations (see syllabus for specific dates) each worth 100 points. Absolutely NO make-up exams will be given. All examinations will be on-campus Monday's from 10:00AM-11:40AM.

 

Note: Exam 1 will be available online from 8:00AM-8:00PM , Monday February 14th, and will requires the Respondus Lockdown Browser.

Exam 1 is multiple choice, 34 questions, presented randomly one-at-a-time, you may return to previous questions.

 

7. Final Exam: The final exam (100 pts), will be on-line through Bb Collaborate Ultra using the Respondus Lockdown Browser and is scheduled for Monday, May 16th, 2022, and will be available from 8:00AM until 8:00PM. The exam will consist of 50 multiple choice questions presented randomly, one-at-a-time, each worth 2 pts, you will have 120 minutes to complete the exam.

 

8. Homework:

9. The Goal of this course is to understand and outline Proteins, Enzymes, Vitamins, Membranes and all of the Carbohydrate Metabolic Pathways.

 

10. Grading Criteria: Letter grades are based on the following point distribution. Grades are criterion-referenced not norm-referenced; each student has an equal opportunity meet the criteria charted below:

 

Homework 200 pts
Exams 400 pts
Final Exam 100 pts
Total 700 pts

 

Grade

Percentages

Grade

Percentages

A

100-91

A-

90-89

B+

88-87

B

86-81

B-

80-79

C+

78-77

C

76-71

C-

70-69

D+

68-67

D

66-60

F

59-0

 

11. Case Studies/Clinical Correlates: Related directly to the general biochemical principles being taught are intended to give "real-life" significance to the biochemistry experience and should be printed from the web site.


12. Course Description: The chemistry of amino acids and proteins; the chemistry and metabolism of carbohydrates and lipids; energetics in living systems.  The course is taught with a medical emphasis and covers peptides, proteins, myoglobin/hemoglobin, enzymes, vitamins, catecholamines and metabolism, as well as, clinical correlates and case studies.


13. Academic Integrity Statement: A university is a community of learners bonded together by the search for knowledge; the pursuit of personal, social, cultural, physical, and intellectual development; and the desire for the liberating effects of an advanced education.  California State University, Dominguez Hills (CSUDH) has a culture--an academic culture--shared with other universities and colleges across the nation.  Integral to that culture is a set of values such as academic freedom, dedication to teaching and learning, diversity, civility toward others, and academic integrity.  Academic integrity is of central importance in the university community and involves committed allegiance to the values, the principles, and the code of behavior held to be central in that community.  Integrity concerns honesty and implies being truthful, fair, and free from lies, fraud and deceit.


14. Disabled Student Services: CSUDH adheres to the American with Disabilities Act with respect to providing reasonable accommodations for students with temporary or permanent disabilities. To receive accommodations, students with disabilities must register with Disabled Student Services. For more information, please contact their office in Welch Hall B250 at (310) 243-3660 or (310) 243-2028.

 

Tentative Syllabus

Note: On-campus sessions Monday's, are in italics and meet in II 3350 at 10:00AM.

Date Lecture Reading (Lehninger: Principles of Bicohemistry, 8th Edition) Case Study Homework
January 24

Foundations of Biochemistry

Ch. 1: Lehninger Introductory Ppt

Chapter 1

 

Chapter 1

DUE: Wednesday, 01/26

January 26

Acidosis / Alkalosis

Ch. 2: Lehninger Water Ppt

Chapter 2

Case Study

Solution

Chapters 2

DUE: Friday, 01/28

 

January 31

Amino Acids / Proteins

Ch. 3: Lehninger Amino Acids, Peptides and Proteins Ppt

Chapter 3

Case Study

Solution

Chapter 3

DUE Wednesday, 02/02

February 02

Protein Synthesis and Maturation

Ch. 27: Lehninger Protein Metabolism Ppt

Chapter 27

 

Chapter 27

DUE: Friday, 02/04

February 07

Proteins: 3D Structure

Ch. 4: Lehninger 3D Structure of Proteins Ppt

Chapter 4  

Chapter 4

DUE: Friday, 02/11

February 09

Exam 1 On-line Q & A and Problem Solving Session

 

 

February 14 Exam 1      
February 16

Membranes

Ch. 11: Lehninger Membranes Ppt

Chapter 11

Chapter 11 8th Ed

 

Chapter 11

DUE: Friday, 02/18

February 21

HOLIDAY

 

 

 

February 23

Hemoglobin and Antibodies

Ch. 5: Lehninger Protein Function Ppt

Chapter 5

Case Study

Solution

Chapter 5

DUE: Friday, 02/25

February 28

Enzymes: Catalysis & Kinetics

Ch. 6: Lehninger Enzymes Ppt

Chapter 6

Case Study

Solution

 

March 2

Enzymes: Isozymes, Regulation & Mechanisms

Ch. 6: Lehninger Enzymes Ppt

" "  

Chapter 6

DUE: Friday, 03/04

March 07

Overview of Nutrients / Vitamins of CHO Metabolism

Intro To & Thermo Of Metabolism

Ch. 13: Lehninger Introduction to Metabolism Ppt

Chapter 13

NADH and FADH2 Structures

 

Chapter 13

DUE: Wednesday, 03/09

March 09

Exam 2 On-line Q & A and Problem Solving Session

 

 

March 14

Exam 2

   

 

March 16

Overview of CHO Metabolism

Glucose Transport

Ch. 7: Lehninger Carbohydrates Ppt

Chapter 7  

Chapter 7

DUE: Friday, 03/18

March 21**

Glycolysis, Gluconeogenesis and the PPP

Ch. 14: Lehninger Glycolysis, Gluconeogenesis and the PPP Ppt

Chapter 14

 

Chapter: 14

DUE: Wednesday, 03/23

March 23

Citric Acid Cycle

Ch. 16: Lehninger The Citric Acid Ppt

Chapter 16

Case Study

Solution

Chapter 16

DUE: Friday, 03/25

March 28

SPRING BREAK

 

 

March 30

SPRING BREAK


 

April 04

Electron Transport

Electron Transport pdf

Ch. 19: Lehninger Oxidative Phosphorylation Ppt

Chapter 19

Case Study

Solution

Chapter 19

DUE: Wednesday, 04/06

April 06

Glycogen Metabolism

Ch. 15: Lehninger Glycogen Metabolism

CHO Pathways Overview

Chapter 15  

Chapter 15

DUE: Friday, 04/08

  Exam 3 On-line Q & A and Problem Solving Session      
April 11

Exam 3

 

April 13

Nucleotides: Composition and Structure

Ch. 8: Lehninger Nucleotides and Nucleic Acids Ppt

Chapter 8

 

AT and GC Pair Structures

Chapter 8

DUE: Friday, 04/15

April 18

Purine Metabolism (Study Guide)

Pyrimidine Metabolism (Study Guide)

Ch. 22: Lehninger Nucleotide Synthesis Ppt

Chapter 22

Case Study

Solution

Chapter 22

DUE: Wednesday, 04/20

 

 

April 20

 

DNA Synthesis, Mutation and Repair

Ch. 25: Lehninger DNA Metabolism Ppt

Chapter 25

 

Chapter 25

DUE: Friday, 04/22

April 25

RNA Synthesis and Processing

Ch. 26: Lehninger RNA Metabolism Ppt

Chapter 26

 

Chapter 26

DUE: Wednesday, 04/27

April 27

Genome Organization

Ch. 24: Lehninger Genes and Chromosomes Ppt

Chapter 24

Study Guide/Worksheet:

Genome Organization

Chapter 24

DUE: Friday, 04/29

May 02

Regulation of Gene Expression

Ch. 28: Lehninger Regulation of Gene Expression Ppt

Chapter 28

Study Guide/Worksheet:

 

Regulation of Gene Expression

 

 

Chapter 28

DUE: Wednesday, 05/04

May 04

Exam 4 On-line Q & A and Problem Solving Session

 

 

May 09 Exam 4      
May 11 Final Exam On-line Q & A and Problem Solving Session      
Monday, May 16th Final Exam, On-line 8:00AM-5:00PM    

**NOTE: March 21st is a Monday but we will meeting on-line using bb Collaborate Ultra.

Homework Assignment DUE DATE (11:59PM)

Log into Blackboard and then navigate to this course.
Click the "Homework" menu link.

Chapter 1 Wednesday, 01/26, 2022

Chapters 2

Friday, 01/28, 2022

Chapter 3

Wednesday, 02/02, 2022

Chapter 27

Friday, 02/04, 2022

Chapter 4 Friday, 02/11, 2022

Chapter 11

Friday,02/18, 2022

Chapter 5

Friday,02/25, 2022

Chapter 6

Friday, 03/04, 2022

Chapter 13 Wednesday, 03/09, 2022
Chapter 7 Friday, 03/18, 2022

Chapter 14

Wednesday, 03/23, 2022

Chapter 16

Friday,03/25, 2022

Chapter 19

Wednesday, 04/06, 2022

Chapter 15

Friday, 04/08, 2022

Chapter 8 Friday, 04/15, 2022  
Chapter 22 Wednesday, 04/20, 2022  
Chapter 25 Friday, 04/22, 2022  
Chapter 26 Wednesday, 04/27, 2022  
Chapter 24 Friday, 04/29, 2022  
Chapter 28 Wednesday, 05/04, 2022  

 

 

© Dr. Noel Sturm 2022

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